Pregnancy/Lactation: Use with caution, particularly during the third trimester, immediate postpartum period (increased risk of maternal hemorrhage). Excreted primarily in the urine.Not removed by hemodialysis. Well absorbed after subcutaneous administration. Bacterial endocarditis, hemorrhagic stroke, history of heparin-induced thrombocytopenia (HIT), severe hepatic disease. When neuraxial anesthesia (epidural or spinal anesthesia) or spinal puncture is used, pts anticoagulated or scheduled to be anticoagulated with enoxaparin for prevention of thromboembolic complications are at risk for developing an epidural or spinal hematoma that can result in long-term or permanent paralysis. Not for IM use.Ĭautions: Conditions with increased risk of hemorrhage, platelet defects, renal impairment (renal failure), elderly, uncontrolled arterial hypertension, history of recent GI ulceration or hemorrhage. Active major bleeding, concurrent heparin therapy, hypersensitivity to heparin, pork products, thrombocytopenia associated with positive in vitro test for antiplatelet antibodies. Precautions of EnoxaparinĬontraindications: Hypersensitivity to enoxaparin. PHARMACOTHERAPEUTIC: Low molecular weight heparin.īLACK BOX ALERT ■ Epidural or spinal anesthesia greatly increases the potential for spinal or epidural hematoma, subsequent long-term or permanent paralysis. Does not significantly influence PT, aPTT. Therapeutic Effect: Produces anticoagulation. Potentiates action of antithrombin III, inactivates coagulation factor Xa. Bariatric surgery, mechanical heart valve to bridge anticoagulation, percutaneous coronary intervention (PCI) adjunctive therapy. OFF-LABEL: DVT prophylaxis following moderate-risk general surgery, gynecologic surgery management of venous thromboembolism (VTE) during pregnancy. Treatment of DVT with or without pulmonary embolism (PE) (inpatient) without PE (outpatient). Treatment of acute coronary syndrome (ACS): unstable angina, non–Q-wave MI, acute ST-segment elevation MI (STEMI). Indications/routes/dosage of EnoxaparinĭVT prophylaxis following hip or knee replacement surgery, abdominal surgery, or pts with severely restricted mobility during acute illness.
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